| 摘要 |
PURPOSE:To produce the subject compound useful e.g. as an intermediate for pharmaceuticals, etc., in high efficiency, optical purity and yield by treating a specific racemic alpha-methylalkanedicarboxylic acid diester with a cultured product, etc., of a specific mlcroorganism. CONSTITUTION:This (R)-isomer of an alpha-methylalkanedicarboxylic acid omega- monoester of formula II and (S)-isomer of an alpha-methylalkanedicarboxylic acid diester of formula III are produced by treating a racemic alpha- methylalkanedicarboxylic acid diester of formula I (R is a 1-6C alkyl; (n) is 1 or 2) with a cultured product, cells or treated cells of a microorganism belonging to the genus Pseudomonas or Escherichia and capable of asymmetrically hydrolyzing an ester bond [e.g. Pseudomonas putida MR-2068 (FERM BP-3846)]. |
