ANTIFUNGAL ANTIBIOTIC BU-3608 COMPLEX

摘要

Disclosed herein are N-alkyl derivatives of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents. They have the following structure: <IMG> II wherein R1 is H, or R1 is methyl and the resulting alanyl is D-alanyl; R2 is H or .beta.-D-xylosyl; and Y is NR3R4 or +NR3R4R5 X-; wherein R3, R4 and R5 are the same or different C1-5alkyl; and X- is a chloride ion; or a pharmaceutically acceptable salt thereof.