发明名称 |
Retroviral gene therapy vectors and therapeutic methods based thereon |
摘要 |
Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclosed are retroviral vectors lacking a selectable marker, thus rendering them suitable for human gene therapy in the treatment of a variety of disease states without the co-expression of a marker product, such as an antibiotic. These retroviral vectors are especially suited for use in certain packaging cell lines. |
申请公布号 |
AU2637695(A) |
申请公布日期 |
1996.01.05 |
申请号 |
AU19950026376 |
申请日期 |
1995.05.16 |
申请人 |
SOMATIX THERAPY CORPORATION;WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
ISABELLE RIVIERE;LAWRENCE K COHEN;BRAD GUILD;LORI F RAFIELD;PAUL ROBBINS;RICHARD C. MULLIGAN |
分类号 |
C12N15/09;A61K35/12;A61K38/00;A61K38/19;A61K38/37;A61K38/46;A61K38/49;A61K48/00;A61L27/00;A61L27/38;A61L33/18;A61P7/00;C07K14/635;C07K14/705;C07K14/755;C12N5/071;C12N5/10;C12N9/38;C12N9/72;C12N9/78;C12N15/867 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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