| 摘要 |
New 9,12-epoxycyclohexano[3,4-c]cephalosporins of formula (I) are prepared starting from the corresponding ester obtained reacting a 7-phenylacetamido-3-cephem-4-carboxylic acid having in position 3 a leaving group, with furan, optionally 2-substituted or 2,5-disubstituted in the presence of a base, subsequent deacylation and possible reacylation in 7, elimination of the ester group of the obtained product and possibly salification or esterification, giving a pharmaceutically acceptable compound. The new products thus obtained are antibiotics with an excellent activity. |
