2,4,6-TRIIODO-5-SUBSTITUTED-AMINO-ISOPHTHALATE ESTERS USEFUL AS X-RAY CONTRAST AGENTS FOR MEDICAL DIAGNOSTIC IMAGING

摘要

Compounds having structure (I) wherein Q is (II); n is an integer from 0 to 20; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R2, R3, R4 and R5 are independently H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido; R6 is alkyl, cycloalkyl, aryl or aralkyl; and R7 is H or -COR6 are useful as contrast agents in medical diagnostic x-ray imaging compositions and methods.