IMPROVEMENTS IN OR RELATING TO DELIVERY OF NUCLEIC ACIDS

摘要

Disclosed is a recombinant viral particle capable of delivering a nucleic acid to mammalian cells, said particle comprising a member of a first specific binding pair capable of binding to a first receptor expressed on the surface of a cell so as to cause infection thereof, and a surface-exposed member of a second specific binding pair capable of binding to a second receptor generally not expressed on the surface of the cell, such that binding of the viral particle to the second receptor via the member of the second specific binding pair inhibits infection of the cell by the viral particle. Also disclosed is a composition comprising the recombinant viral particle defined above, and methods of altering the host range of a viral particle.