IN SITU GEL-FORMING DELIVERY VEHICLE FOR BIO-AFFECTING SUBSTANCES, AND METHOD OF USE

摘要

An interpolymer complex of a polyacid and a water-soluble, non-ionic polymer, preferably polymethacrylic acid and polyethyleneglycol, which forms a stable, insoluble complex in water at acidic pH, and which is converted to an extrudable liquid upon addition of an appropriate amount of a complex solubilizer, preferably ethanol. The resultant complex is particularly useful as an injectable, sustained release delivery vehicle for bio-affecting substances, including therapeutic agents.