摘要 |
<p>PCT No. PCT/GB95/00024 Sec. 371 Date Aug. 5, 1998 Sec. 102(e) Date Aug. 5, 1998 PCT Filed Jan. 6, 1995 PCT Pub. No. WO95/18807 PCT Pub. Date Jul. 13, 1995The present invention is based on the discovery that certain 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives of formula I or a pharmaceutically acceptable salt thereof are useful as antitumor agents against sensitive and resistant tumor cells. Wherein X is NH or O, and R is defined in the specification.</p> |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD.;SYNPHAR LABORATORIES INC. |
发明人 |
SINGH, RAJESHWAR;YAMASHITA, TOMOHIRO;FIAKPUI, CHARLES;THOMAS, GEORGE;HA, CHAN;MATSUMOTO, HIROSHI;OTANI, TOSHIO;OIE, SHINJI;MICETICH, RONALD |