4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof

摘要

PCT No. PCT/JP92/01139 Sec. 371 Date Mar. 7, 1994 Sec. 102(e) Date Mar. 7, 1994 PCT Filed Sep. 4, 1992 PCT Pub. No. WO93/05021 PCT Pub. Date Mar. 18, 1993.4-Amino(alkyl)cyclohexane-1-carboxamide compounds of the formula (I) <IMAGE> (I) wherein each symbol is as defined in the Specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. The 4-amino(alkyl)cyclohexane-1-carboxamide compounds, isomers thereof and pharmaceutically acceptable acid addition salts thereof of the present invention have potent and long-lasting coronary, cerebral, renal and peripheral blood flow increasing actions and are less toxic, and thus are useful as a potent and long-lasting antihypertensive agent and an agent for the prevention and treatment of diseases in the circulatory organs such as coronary, cerebral, renal and peripheral arteries. Moreover, the compounds of the present invention exhibit inhibitory action on experimental asthma of guinea pigs, which is caused by histamine inhalation, and inhibitory action on contraction of trachea strips isolated from guinea pigs, which is caused by acetylcholine, and thus are useful as therapeutic agents for asthma.