Method of chiral epoxidation of benzopyran or pyranopyridine derivatives using microorganisms

摘要

An enzymatic process for the preparation of chiral epoxides, monohydroxy or dihydroxy compounds of formula <IMAGE> I <IMAGE> II by the stereoselective epoxidation or hydroxylation of benzopyrans of formula <IMAGE> III or resolution of compounds of formula <IMAGE> IIa The compounds of formula I and II are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.