PREPARATION OF STEREOCHEMICALLY PURE OXIMES WITH MUSCARINIC ACTIVITY

摘要

The instant invention is a selective formation of the Z-oxime and O-alkylation of 1-azabicyclo-(2.2.1)heptan-3-one and 1-azabicyclo(2.2.2)heptan-3-one oximes (I) to produce compounds with muscarinic activity. The process is capable of scale-up for industrial purposes as it provides better yields and ease of preparation. Intermediates are also described.