发明名称 |
PHENYL-SUBSTITUTED ALKENYLCARBOGUANIDIDES CARRYING PERFLUOROALKYL GROUPS, A PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT OR DIAGNOSTIC AGENT, AND ALSO A MEDICAMENT CONTAING THEM |
摘要 |
Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them. Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, of the formula I I in which the substituents have the meanings stated in the description, and their pharmaceutically suitable salts, are described. They are obtained by reacting a compound II with guanidine, in which R(1) to R(5) and R(A), R(B), R(C) and R(D) have the stated meaning, and L is a leaving group which easily undergoes nucleophilic substitution. Compounds I are excellent cardiovascular therapeutic agents.
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申请公布号 |
CA2152137(A1) |
申请公布日期 |
1995.12.21 |
申请号 |
CA19952152137 |
申请日期 |
1995.06.19 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
SCHWARK, JAN-ROBERT;KLEEMANN, HEINZ-WERNER;LANG, HANS-JOCHEN;WEICHERT, ANDREAS;SCHOLZ, WOLFGANG;ALBUS, UDO |
分类号 |
A61K31/165;A01N1/02;A61K31/16;A61P9/00;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P31/04;A61P35/00;A61P37/08;C07C277/08;C07C279/22;(IPC1-7):C07C279/22;C12Q1/02;G01N33/84 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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