PROCESS FOR PRODUCING POLYVALENT AND PHYSIOLOGICALLY DEGRADABLE CARBOHYDRATE RECEPTOR BLOCKERS BY ENZYMATIC GLYCOSYLATION REACTIONS, AND USES THEREOF FOR MANUFACTURING CARBOHYDRATE COMPONENTS

摘要

A process for preparing polyvalent and physiologically degradable carbohydrate receptor blockers by enzymatic glycosylation reactions and the use thereof for preparing carbohydrate building blocks The invention relates to a process for preparing polyvalent polymer-based carbohydrate receptor blockers which cause no intolerance reactions in vivo either in their entirety or in the form of degradation products. The carbohydrate side chain of the receptor blocker is assembled by enzymatic glycosylation reactions in aqueous buffer systems and homogeneous phase directly on the biodegradable polymer; the yields of the glycosylation reaction being considerably improved by comparison with the yields of known processes, as a rule taking place quantitatively and distinctly increasing the loading densities. Furthermore, a process for preparing the free oligosaccharides by means of the carbohydrate receptor blocker is prepared according to the invention is proposed.