METHODS FOR REDUCING HYPERACUTE REJECTION OF XENOGRAFTS
摘要
A method for reducing xenograft rejection is provided wherein a vector directing the expression of a protein having glycosyltransferase activity is introduced into xenogeneic cells. Cells so prepared exhibit a substantial reduction in their binding to naturally occuring preformed human antibodies and are thus protected from hyperacute rejection.
申请公布号
CA2192660(A1)
申请公布日期
1995.12.21
申请号
CA19952192660
申请日期
1995.06.14
申请人
ALEXION PHARMACEUTICALS, INC.;AUSTIN RESEARCH INSTITUTE (THE)
发明人
SANDRIN, MAURO S.;FODOR, WILLIAM L.;ROTHER, RUSSELL P.;SQUINTO, STEPHEN P.;MCKENZIE, IAN F. C.