| 摘要 |
<p>Novel pyridyl imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity, wherein A is a straight, branched or cyclic C1-C6 alkyl or alkenyl group, OR1 (wherein R1 is a hydrogen, or a straight, branched or cyclic C¿1?-C6 alkyl or alkenyl radical), or NR?2R3¿ (wherein R?2 and R3¿ are independently a hydrogen, or a straight, branched or cyclic C¿1?-C6 alkyl radical); B is a group of formula (II); D is a hydrogen; a halogen; a straight, branched or cyclic C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R?1, COR1, CON(R1)¿2 or N(R1)2, wherein R1 is the same as defined above; tetrazol-5-yl; a perfluoro-C¿1?-C4 alkyl group; or N(R?1)¿2, OR1, CO2R1 or CON(R1)2, wherein R1 is the same as defined above; E is a hydrogen; a halogen; a straight or branched C¿1?-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R?1, COR1, CON(R1)¿2 or N(R1)2, wherein R1 is the same as defined above; a perfluoro-C¿1?-C4 alkyl group; NO2; or N(R?1)¿2 or OR1, wherein R1 is the same as defined above; and n is 0 or an integer of 1 to 4.</p> |
