Flt-4 (fms-like tyrosine-kinase), flt-15, variants thereof uses as growth factor inhibitors

摘要

PCT No. PCT/GB95/01213 Sec. 371 Date May 12, 1997 Sec. 102(e) Date May 12, 1997 PCT Filed May 26, 1995 PCT Pub. No. WO95/33050 PCT Pub. Date Dec. 7, 1995Disclosed is an altered, soluble form of the FLT polypeptide being capable of binding to VEGF and thereby exerting an inhibitory effect thereon, the polypeptide comprising five or fewer complete immunoglobulin-like domains, together with pharmaceutical compositions comprising the polypeptide, and various uses thereof.