发明名称 |
INHIBITION OF HUMAN XENOGENIC OR ALLOGENIC ANTIBODIES TO REDUCE XENOGRAFT OR ALLOGRAFT REJECTION IN HUMAN RECIPIENTS |
摘要 |
Reactivity between an alloantigen and an anti-alloantigen is indicative of immunological reactivity between two biological samples of the same species. Reactivity between a xenoantigen and an anti-xenoantigen is indicative of immunological reactivity between two biological samples of different species. In many cases both of the reactions are indicative of an antibody-mediated rejection. Anti-antibodies can be employed to reduce cross-reactivity in many transplantation-type situations, either within a similar species, or across species lines. These anti-antibodies are prepared against the antibodies responsible for the antibody-mediated rejection. These anti-antibodies can then be used in vivo or in vitro to complex with the antibodies thus reducing or eliminating reactivity between an alloantigen and an anti-alloantigen or reactivity between a xenoantigen and an anti-xenoantigen between any two species combinations. These antibodies may also be used to target and eliminate the B-cells that produce anti-xenogenic antibodies.
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申请公布号 |
CA2193060(A1) |
申请公布日期 |
1995.12.21 |
申请号 |
CA19952193060 |
申请日期 |
1995.06.14 |
申请人 |
SPECTRAL DIAGNOSTICS, INC.;HOSPITAL FOR SICK CHILDREN (THE) |
发明人 |
COLES, JOHN G.;TAKAHASHI, MIYOKO;YOUNG, DAVID S. F.;BROCKHAUSEN, INKA |
分类号 |
G01N33/53;A61K38/00;C07K16/42;C12N15/02;C12P21/08;C12R1/91;(IPC1-7):C07K16/42;C07K16/28;A61K39/395;G01N33/554;G01N33/564 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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