发明名称 |
Inducible defensin peptide from mammalian epithelia |
摘要 |
The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP. |
申请公布号 |
AU2654395(A) |
申请公布日期 |
1995.12.18 |
申请号 |
AU19950026543 |
申请日期 |
1995.05.24 |
申请人 |
MAGAININ PHARMACEUTICALS INC. |
发明人 |
BARRY S SCHONWETTER;MICHAEL A ZASLOFF |
分类号 |
A61K38/00;C07K14/47;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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