| 摘要 |
PCT No. PCT/US95/06286 Sec. 371 Date Nov. 6, 1996 Sec. 102(e) Date Nov. 6, 1996 PCT Filed May 16, 1995 PCT Pub. No. WO95/32191 PCT Pub. Date Nov. 30, 1995The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer, which compound has the structure; <IMAGE> or a pharmaceutically acceptable salt or disulfide thereof and wherein the variables are as defined in the specification./! |
