发明名称 |
Novel potent inducers of terminal differentiation and methods of use thereof |
摘要 |
This invention is directed to compounds having the structure: <IMAGE> wherein R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine or thiazoleamino group; when R1 and R2 are different, R1=R3-N-R4, and n is an integer from about 4 to about 8. This invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. The invention further provides pharmaceutical compositions comprising a therapeutically effective amount of the compounds of the present invention and a pharmaceutically acceptable carrier. |
申请公布号 |
AU2647495(A) |
申请公布日期 |
1995.12.18 |
申请号 |
AU19950026474 |
申请日期 |
1995.05.19 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
RONALD BRESLOW;PAUL A. MARKS;RICHARD A. RIFKIND |
分类号 |
C07D295/18;A61K31/16;A61K31/164;A61K31/165;A61K31/167;A61K31/192;A61K31/197;A61K31/20;A61K31/216;A61K31/221;A61K31/275;A61K31/277;A61K31/425;A61K31/426;A61K31/427;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/445;A61K31/4453;A61K31/52;A61P35/00;A61P35/02;A61P43/00;C07C229/24;C07C229/30;C07C233/05;C07C233/06;C07C233/07;C07C233/15;C07C233/25;C07C233/34;C07C233/36;C07C233/43;C07C233/54;C07C233/64;C07C233/92;C07C237/04;C07C237/42;C07C255/19;C07C255/42;C07C255/44;C07C255/60;C07C259/06;C07C259/08;C07C259/10;C07C271/10;C07C271/28;C07C275/28;C07D211/16;C07D211/26;C07D211/32;C07D213/56;C07D213/75;C07D277/02;C07D277/20;C07D277/44;C07D277/46;C07D295/185;C07D487/04;C07D519/00 |
主分类号 |
C07D295/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|