Sequence-specific endonucleases, and preparation and use of same

摘要

RNase P RNA conjugates which function as sequence-specific endonucleases are described. Preferred conjugates include a covalently-attached Internal Guide Sequence that binds exogenous RNA substrates via Watson-Crick basepairing. This, in effect, converts a structure-specific ribozyme into a sequence-specific ribozyme useful inter alia in antiviral and other therapies.