| 摘要 |
New taxoids having general formula (I), (II), preparation thereof and pharmaceutical compositions containing them. In the general formula (I), R is alkyl radical (1-6 carbon atoms), alkenyl (2-6 carbon atoms), alkynyl (2-6 carbon atoms), cycloalkyl (3-6 carbon atoms), cycloalkenyl (4-6 carbon atoms), phenyl, unsaturated heterocyclyl containing from 5 to 6 links, Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl, thenoyl or furoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl, R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or aromatic heterocyclic radical. The new products of general formula (I) wherein Z is a radical having general formula (II) have remarkable antitumoral and antileukaemic properties. |
