| 摘要 |
<p>A process suited for industrially mass-producing a 4-oxo-2-alkenoic ester which serves as a starting material for producing a lignan derivative useful as an antihyperlipemic and is represented by general formula (I) (wherein R1 represents lower alkyl, etc.; and R2 represents lower alkyl), which process comprises reacting a malic acid derivative represented by general formula (II) (wherein R2 is as defined above; R3 represents lower alkylcarbonyl; and X1 represents halogen) with a grignard reagent represented by the general formula (III): R1 -MgX2 (wherein R1 is as defined above; and X2 represents halogen) in the presence of a transition metal catalyst, and decarboxylating the reaction product.</p> |
