Thiazolidine and oxazolidine derivatives their preparation and their medical use

摘要

Compounds of formula (I): [in which: R<1> and R<2> are each hydrogen or alkyl, or together a group of formula -(CH2)k- in which k is an integer; R<3> is hydrogen, alkyl, alkoxy, halogen or hydroxy; A and B are each hydrogen, alkyl, aralkyl, aliphatic carboxylic acyl, aryl-substituted aliphatic carboxylic acyl, aromatic carboxylic acyl or carbamoyl, or A and B together represent >C=O, >C=S, -C(=O)-C(=O)-, -CH2C(=O)-, -CH2CH2-, -SO2- or -CH2SO2-; X is a group of formula: W-(CH2)m-X<1>- in which W is aryl or heterocyclic, X<1> is a single bond, oxygen, sulphur or >NR<4> in which R<4> is hydrogen, alkyl, aralkyl or aryl, and m is 0 or an integer; Y is a group of formula: -(CH2)n-Y<1>-, in which Y<1> is a single bond, oxygen or sulphur, and n is an integer; Z is a group of formula (i), (ii), (iii), (iv), (v) or (vi): in which R<5> is hydrogen, carboxyalkyl, alkanoyloxyalkyl, cycloalkyl-substituted alkanoyloxyalkyl, cycloalkylcarbonyloxyalkyl, alkoxycarbonyloxyalkyl, cycloalkyl-substituted alkoxycarbonyloxyalkyl or cycloalkyloxycarbonyloxyalkyl group]; and salts, esters and solvates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.