NEW TAXOIDS, PREPARATION THEREOF AND PHAMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

New taxoids having general formula (I), (II), preparation thereof and pharmaceutical compositions containing them. In general formula (I), Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy and Rb is hydrogen or Ra and Rb form together with the carbon atom to which they are linked a ketone function; Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl radical, thenoyl or furoyl or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or heterocyclic aromatic radical, and R4 and R5, which are the same or different, represent an alkyl, alkenyl, alkynyl, cycoalkyl, cycloalkenyl, bicycloalkyl, aryl, or heterocyclyl radical, R5 not representing a methyl radical. The new products having general formula (I) wherein Z is a radical of general formula (II) have remarkable antitumoral and antileukaemic properties.