发明名称 |
NOVEL 1,1-BIS(HETEROAZOLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS |
摘要 |
The present invention relates to novel heterocyclic compounds having general formula (1), wherein: X1 and X2 are independently O, S or Se; Y1 and Y2 are independently C or N with the proviso that at least one of Y1 and Y2 is N; Y3 and Y4 are independently C or N with the proviso that at least one of Y3 and Y4 is N; R1 and R2 each represent one or more groups independently selected from H, lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl, lower acyloxy-lower alkyl or CF3; and A is (a) or (b) geometrical and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof; having therapeutic activity, processes and intermediates for their preparation, pharmaceutical formulations containing said compounds and the medicinal use of said compounds.
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申请公布号 |
WO9533747(A1) |
申请公布日期 |
1995.12.14 |
申请号 |
WO1995SE00604 |
申请日期 |
1995.05.29 |
申请人 |
ASTRA AKTIEBOLAG;BOAR, BERNARD, ROBIN;GRAY, DUNCAN, ALASTAIR;O'SHEA, DENNIS, MARK |
发明人 |
BOAR, BERNARD, ROBIN;GRAY, DUNCAN, ALASTAIR;O'SHEA, DENNIS, MARK |
分类号 |
C07D413/06;A61K31/395;A61K31/41;A61K31/42;A61K31/421;A61K31/422;A61K31/4245;A61K31/425;A61K31/426;A61K31/427;A61P9/08;A61P9/10;A61P25/00;A61P25/28;C07D261/08;C07D263/32;C07D271/04;C07D277/20;C07D277/22;C07D277/24;C07D277/26;C07D277/28;C07D277/34;C07D293/06;C07D417/06;C07D421/06;(IPC1-7):C07D417/06 |
主分类号 |
C07D413/06 |
代理机构 |
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地址 |
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