4-ARYL-1-(INDANMETHYL, DIHYDROBENZOFURANMETHYL OR DIHYDROBENZOTHIOPHENEMETHYL)PIPERIDINES, TETRAHYDROPYRIDINES OR PIPERAZINES

摘要

4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH2 and the other one is CH2, O or S; Z is N, C, CH or COH; Ar is an optionally substituted aryl group; R<1> is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, acyl, thioacyl, alkylsulfonyl, trifluoromethylsulfonyl, arylsulfonyl, a group R<9>VCO- where V is O or S and R<9> is alkyl or aryl, or a group R<10>R<11>NCO- or R<10>R<11>NCS- wherein R<10> and R<11> are hydrogen, alkyl or aryl, or R<10> and R<11> are linked to form a ring; R<2> is hydrogen, alkyl, cycloalkyl or cycloalkylalkyl; or R<1> and R<2> are linked to form a ring; R<3> - R<5> are hydrogen, halogen, alkyl, alkylcarbonyl, phenylcarbonyl, alkoxy, alkylthio, hydroxy, alkylsulfonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkylalkyl or nitro; R<6> and R<7> are hydrogen or alkyl or they are linked to constitute 3-7-membered ring; R<8> is hydrogen or alkyl; have effects at central serotonergic receptors and are therefore useful in the treatment of certain psychic and neurologic disorders.