发明名称 |
METHOD AND PROBES FOR DETECTING MARKERS BOUND TO THE LOCUS OF CHILD SPINAL MUSCULAR ATROPHIES |
摘要 |
Method for the study of the chromosomic region believed to contain a gene involved, either by its presence or its absence, in child spinal muscular atrophy (SMA) and obtained from a patient or foetus suffering from said diseases or susceptible to said diseases. The method of the invention comprises contacting a chromosomic DNA sample from said person or foetus with a DNA strand capable of recognizing the polymorphic markers in the 5q13 chromosomal region under amplification conditions for extending its chains to and beyond the repeated sequences of said markers; then discriminating between the extended chains obtained on the basis of their respective lengths, to obtain data representative of the number of said markers. |
申请公布号 |
CA2191880(A1) |
申请公布日期 |
1995.12.14 |
申请号 |
CA19952191880 |
申请日期 |
1995.06.02 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
MELKI, JUDITH;MUNNICH, ARNOLD |
分类号 |
C12N15/09;C07K14/475;C12N15/12;C12Q1/68;(IPC1-7):C12N15/12;C07H21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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