发明名称 |
Process for penems |
摘要 |
<p>There is provided a process for the preparation of compounds of formula (I) useful as antibacterials: <CHEM> wherein R represents hydrogen atom or a hydroxy protecting group, which process comprises reacting a compound of formula (II) <CHEM> wherein R is as defined above, with an oxalyl halide in an inert solvent; optionally converting the resultant compound of the formula III <CHEM> wherein R is as defined above and X is a halogen atom into a compound of the formula III in which X represents a hydroxy group by hydrolysis; either (i) treating the compound of formula III in which X is a halogen atom with a compound of the formula IV <CHEM> wherein Y is a hydroxy group in the presence of an acid scavenger or an organic or inorganic base or (ii) treating the compound of the formula III in which X is a hydroxy group, with a compound of the formula IV in which Y is a leaving group in the presence of a base; cyclizing the resultant compound of the formula V <CHEM> wherein R is as defined above and optionally deprotecting the resultant compound of the formula I wherein R is a hydroxy protecting group to obtain a compound of the formula I wherein R is a hydrogen atom.</p> |
申请公布号 |
EP0406790(B1) |
申请公布日期 |
1995.12.13 |
申请号 |
EP19900112654 |
申请日期 |
1990.07.03 |
申请人 |
PHARMACIA S.P.A. |
发明人 |
PERRONE, ETTORE;ALPEGIANI, MARCO;ZARINI, FRANCO;MAZZINI, GIUSEPPE;FRANCESCHI, GIOVANNI |
分类号 |
A61K31/43;A61K31/431;A61P31/04;C07D;C07D317/40;C07D499/06;C07D499/88;C07D499/883;C07D499/897;(IPC1-7):C07D499/88 |
主分类号 |
A61K31/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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