| 摘要 |
PURPOSE:To obtain the new substance, being an acute phase response factor (APRF) of transcript of mammal, useful for supplying and suppressing APRF cytokinin function and suitable for treating inflammatory diseases in which cytokinin participates as APRF function inhibitor. CONSTITUTION:This new polypeptide is an acute phase response factor(APRF) having an amino acid sequence containing an amino acid sequence expressed by the formula and being a transcript of mammal and is participated in intracellular signal transfer of interleukin 6 (IL-6), useful for complementing or suppressing APRF function, capable of utilizing in searching a substance inhibiting the function of APRF and effective in treating various diseases in which cytokinin such as IL-6 are participated, e.g., inflammatory diseases, leukemia, cancer, bone breakage, pulmonary hypertension, etc., as an active ingredient for APRF function inhibitor. Furthermore, its homologue and fragment are provided. The compound is obtained by integrating cDNA isolated from liver or placental cDNA library of mammal into an expression vector and expressing the vector with a host. |
