| 摘要 |
PCT No. PCT/GB92/02182 Sec. 371 Date May 25, 1994 Sec. 102(e) Date May 25, 1994 PCT Filed Nov. 25, 1992 PCT Pub. No. WO93/10783 PCT Pub. Date Jun. 10, 1993.A class of 2(1H)-quinolone derivatives, substituted at the 3-position by a range of carbonyl-containing substitutients or by a five- or six-membered heteroaromatic moiety, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.
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