| 摘要 |
PURPOSE:To efficiently obtain the subject compound useful as a raw material for antimicrobial agents, etc., by treating the mixture of (R) and (S)-1-benzyl-3- hydroxy-2,5-pyrrolidinediones with an acyl group-donating compound in the presence of a lipase originated from a microorganism. CONSTITUTION:The mixture of (R) and (S)-1-benzyl-3-hydroxy-2,5- pyrrolidinediones of formula I (Ph is phenyl) is subjected to an asymmetric esterification reaction with an acyl group-donating compound (e.g. acetic anhydride) in the presence of a lipase originated from the genus Pseudomonas or Candida to obtain an optically active 3-acyloxy-1-benzyl-2,5-pyrrolidinedione of formula II (R is a 1-17C alkyl, an aryl) and/or an optically active 1-benzyl-3- hydroxy-2,5-pyrrolidinedione of formula III having a steric configuration reverse to that of the compound of formula II. |
