| 摘要 |
PCT No. PCT/EP92/02564 Sec. 371 Date May 9, 1994 Sec. 102(e) Date May 9, 1994 PCT Filed Nov. 4, 1992 PCT Pub. No. WO93/10101 PCT Pub. Date May 27, 1993.Benzimidazole anthelmintic agents of the formula (I) and their non-toxic salts, wherein R1, which is in the 5(6)-position, is either H or certain stated substituents, "alk" is a methylene or ethylene group; R2 is cyano, C1-C4alkenyl, C2-C4 alkynyl, C2-C4alkanoyl, C1-C4alkoxy, C2-C4alkenoxy, aryl, heteroaryl, aryl-(C1-C4alkoxy) or heteroaryl-(C1-C4alkoxy), in which "aryl" means phenyl optionally substituted by 1 to 3 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulphinyl, and C1C4alkylsulphonyl in which "heteroaryl" means thienyl, furyl or pyridininyl all optionally substituted by 1 to 3 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulphinyl and C1-C4alkylsulphonyl; and R3 is a C1- C4alkyl group. The anthelmintic agents (I) are, unexpectedly, active topically and parenterally, and are thus suitable for spot-on, pour-on, or parental (especially in tramuscular) administration.
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