摘要 |
Prodn. of lactic-acid-contg, optically active, cyclic depsipeptides with 18 ring atoms with the aid of a Fusarium fungus or an enzyme prepn. isolated from such a fungus is new. Also claimed is the prodn. of lactic-acid-contg. optically active, cyclic depsipeptides with 18 ring atoms (enniatins)of formula (I) from optically active amino acids of formula (II)-(IV), optically active or racemic alpha -hydroxy acids of formula (V) and (VI) and optically active or racemic lactic acid, where the reaction is effected in the presence of a Fusarium fungus in a nutrient medium or in the presence of a microbial synthetase in a buffer system: R1,R2 and R4 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, carboxyalkyl, alkoxycarbonylalkyl, carbamoylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, guanidinoalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2; R3 and R5 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2. |