发明名称 |
NEW LIPID ESTERS OF NUCLEOSIDE MONOPHOSPHATES AND THEIR USE AS IMMUNOSUPPRESSIVE DRUGS |
摘要 |
The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I), wherein R<1> represents an optionally substituted alkyl chain having 1-20 carbon atoms; R<2> represents hydrogen, an optionally substituted alkyl chain having 1-20 carbon atoms; R<3>, R<4> and R<5> represent hydrogen, hydroxy, azido, amino, cyano, or halogen; X represents a valence dash, oxygen, sulfur, a sulfinyl or sulfonyl group; Y represents a valence dash, an oxygen or sulfur atom; B represents a purine and/or pyrimidine base; with the proviso that at least one of the residues R<3> or R<5> is hydrogen; to their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds. |
申请公布号 |
WO9532984(A1) |
申请公布日期 |
1995.12.07 |
申请号 |
WO1995EP01951 |
申请日期 |
1995.05.23 |
申请人 |
BOEHRINGER MANNHEIM GMBH;HERRMANN, DIETER;OPITZ, HANS-GEORG;ZILCH, HARALD;MERTENS, ALFRED |
发明人 |
HERRMANN, DIETER;OPITZ, HANS-GEORG;ZILCH, HARALD;MERTENS, ALFRED |
分类号 |
A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61P31/12;A61P35/00;A61P37/06;C07H19/04;C07H19/10;C07H19/20;C07H19/207 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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