发明名称 |
COORDINATE IN VIVO GENE EXPRESSION |
摘要 |
Nucleic acids, including DNA constructs and RNA transcripts, capable of inducing coordinate expression of two to three cistrons upon direct introduction into animal tissues, are. bi- or tri-cistronic polynucleotides of this invention include those encoding and co-expressing HIV gene products, genes encoding antigens unrelated to HIV, and immunostimulatory gene products, including but not limited to GM-CSF, interleukins, interferon and members of the B7 family of proteins which act as T-cell costimulatory elements. The methods and polynucleotides of this invention are generally applicable to co-ordinate expression in vivo of any two or more genes in a single cell. |
申请公布号 |
WO9524485(A3) |
申请公布日期 |
1995.12.07 |
申请号 |
WO1995US02633 |
申请日期 |
1995.03.03 |
申请人 |
MERCK & CO., INC.;LIU, MARGARET, A.;SHIVER, JOHN, W.;PERRY, HELEN, C. |
发明人 |
LIU, MARGARET, A.;SHIVER, JOHN, W.;PERRY, HELEN, C. |
分类号 |
C12N15/09;A61K9/127;A61K31/70;A61K38/00;A61K38/04;A61K38/16;A61K38/20;A61K38/21;A61K39/00;A61K39/12;A61K39/145;A61K39/21;A61K39/245;A61K39/29;A61K48/00;A61P31/12;A61P35/00;A61P37/04;C07H21/04;C07K14/16;C12N15/12;C12N15/20;C12N15/24;C12N15/27;C12N15/44;C12N15/48;C12N15/85;(IPC1-7):C12N15/18;C07K14/155 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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