NEUROTENSIN ANTAGONIST PEPTIDES

摘要

Compounds of formula (I) in which R is a hydroxy, alkoxy, phenylalkyloxy radical or -NH-CH2-COOH, R1 is a hydrogen atom, an adamantylacetyl, adamantylcarbonyl, norbornylacetyl, norbornylphenoxycarbonyl, benzoyl, nicotinoyl, 4-phenylbenzoyl, 4-tert-butylbenzoyl, 2-pyrrolidinecarbonyl radical or a protective group of an amine function, R2 is an Arg or Lys residue, R3 is an Arg or Lys residue, R4 is a Pro, m, n and p residue, which are the same or different and are a number equal to 0 or 1, given that when R1 is a hydrogen atom, the sum m+n+p is at least equal to 1, R5 and R6 are the same and are a hydroxy or methoxy radical and R7 is a hydrogen, chlorine, bromine or iodine atom or a nitro radical, the equivalents of the compounds of formula (I) in which one or more peptide bonds (CO-NH) between two amino acid residues are replaced by -CH2-NH bonds and/or the peptide bond (CO-NH) between the amino acid residues R2 and R3 is replaced by a CH=CH bond. The invention also concerns the salts of said compounds, the preparation thereof and drugs containing same.