METHOD FOR STABILIZING DUOCARMYCIN DERIVATIVES

摘要

Stabilized duocarmycin derivatives represented by formula (I), wherein R is lower alkyl, allyl or benzyl, and X is Cl or Br, are prepared by adding at least a compound selected from the group consisting of a saccharide, an electolyte, a water-soluble polymer, a polyhydric alcohol and a surfactant to a solution containing the duocarmycin derivatives. Also provided are freeze-dried pharmaceutical preparations containing the stabilized duocarmycin derivatives.