Antiproliferative substituted naphthalene compounds

摘要

The invention relates to TS-inhibiting compounds of the formula where W is an alkylene group; D is a structure having two rings that are unsubstituted or substituted, where (i) one ring is a phenyl ring and (ii) the other ring is a phenyl ring or a 6-membered heterocyclic ring; R is a hydrogen atom or an alkyl group; and X and Y together form and to salts of these compounds. The moiety W can be CH2, and D can be a phenyl ring bridged through a sulfonyl group to another ring.