发明名称 |
METHODS FOR THE IDENTIFICATION OF COMPOUNDS CAPABLE OF ABROGATING HIV-1 Vpr-rip-1 BINDING INTERACTIONS |
摘要 |
A method for treating an individual exposed to or infected with HIV is disclosed which comprises administering to said individual a therapeutically effective amount of one or more compounds which inhibit or prevent replication of said HIV by interfering with the replicative or other essential functions of vpr expressed by said HIV, by interactively blocking the vpr target in human cells, and thereby preventing translocation of the vpr/target complex from the cytosol of said human cells to the nuclei of said cells, where vpr carries on activities essential to replication of HIV. In preferred embodiments, the compound or compounds which interactively block the target are steroid hormone receptor antagonists, glucocorticoid receptor antagonists, or glucocorticoid receptor Type II antagonists, especially mifepristone (RU-486). Pharmaceutical compositions comprising these compounds, as well as a method for identifying them and a kit for use therein, are also disclosed.
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申请公布号 |
WO9531901(A1) |
申请公布日期 |
1995.11.30 |
申请号 |
WO1995US05981 |
申请日期 |
1995.05.17 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;WEINER, DAVID, B.;REFAELI, YOSEF |
发明人 |
WEINER, DAVID, B.;REFAELI, YOSEF |
分类号 |
A61K38/00;C07K14/16;C07K16/10;C12P21/08;G01N33/569;(IPC1-7):A01N31/00;A01N61/00;C07K16/00;C12Q1/70;G01N33/53 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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