| 发明名称 |
PEPTIDES USED AS CARRIERS IN IMMUNOGENIC CONSTRUCTS SUITABLE FOR DEVELOPMENT OF SYNTHETIC VACCINES |
| 摘要 |
The invention relates to conjugates of poorly immunogenic antigens, e.g., peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the sequence of E. coli hsp65 (GroEL), or an analog thereof, said peptide or analog being capable of increasing substantially the immunogenicity of the poorly immunogenic antigen. A suitable peptide according to the invention is Pep287e, which corresponds to positions 437-453 of the E. coli hsp65 molecule.
|
| 申请公布号 |
CA2191202(A1) |
申请公布日期 |
1995.11.30 |
| 申请号 |
CA19952191202 |
申请日期 |
1995.05.24 |
| 申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
COHEN, IRUN R.;FRIDKIN, MATITYAHU;KONENWAISMAN, STEPHANIE |
| 分类号 |
A61K38/00;A61K39/00;A61K39/02;A61K39/112;A61K39/21;A61K39/385;A61K39/39;C07K9/00;C07K14/245;C07K14/725;(IPC1-7):C07K19/00 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
