INTERLEUKIN-6 SPLICE VARIANT

摘要

Human IL-6SV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the polypeptide and antagonists therapeutically to treat platelet reducing conditions, shock syndromes, as an anti-viral agent, to inhibit proliferation of leukemic cells, to improve the toxic activity of human lymphocytes for killing cancer cells, for use in cell transplant therapy, and inflammation. Also disclosed are diagnostic methods for detecting a mutation in the IL-6SV nucleic acid sequences and detecting a level of the polypeptide in a sample derived from a host.