ENANTIOSELECTIVE PREPARATION OF OPTICALLY PURE ALBUTEROL

摘要

The invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of 5-¢2-¢(1,1-dimethylethyl)amino!-1-hydroxyethyl!-2-hydroxybenzoate using di-toluoyltartaric acid. The invention further relates to a method for producing albuterol by the resolution of a mixture of enantiomers of methyl 5-¢2-¢(1,1-dimethylethyl)amino!-1-hydroxyethyl!-2- (phenylmethoxy)benzoate or .alpha.-¢¢(1,1-dimethylethyl)amino!methyl!-4-(phenylm ethoxy)-1,3-benzenedimethanol using a chiral acid such as (+/-) di-toluoyltartaric acid or (+/-) di-benzoyltartaric acid.