N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them.

摘要

N-Pyridyl carboxamides of formula (I), and their salts, enantiomers and diastereoisomers, are new. Q = 2- or 3- pyridyl (opt. as the N-oxide), substd. by R1-R4; R1, R2 = amino, alkylamino, dialkylamino, alkyl, OH, alkoxy, NO2, or halogen; R3, R4 = H or as R1; R = H or alkyl; A = alkylene or alkenylene (both opt. substd by alkyl) or a bond; Y = pyrazine, benzothiophene, 4-oxoÄ4HÜbenzopyran, pyrrole, pyrroline, pyrrolidine, piperidine, pyridine, or phthalimido, (all substd. by one or more R'), or chroman or benzopyran (both opt. substd. by one or more alkyl), 3-carboxy-5-alkyl-isoxazole or 3-alkoxycarbonyl-5-alkyl-isoxazole; and when A is not a bond, Y may also be thiophene (opt. substd. by one or more R'); R' = alkyl, alkoxy, CF3, OH, halogen, thiol or alkylthio; X = O, S, NH, or NR"; R" = alkyl, alkoxy, OH, NH2, arylalkyloxy, or aryloxy. Alkyl and alkoxy have 1-6C; aryl is phenyl or naphthyl; alkenylene has 2-6C.