High-affinity ligands of insulin receptor antibodies, tachykinin substance p, hiv integrase and hiv-1 reverse transcriptase

摘要

Methods are described for the identification and preparation of high-affinity ligands to insulin receptor antibodies, substance P, HIV integrase and HIV-Reverse Transcriptase. Included in the invention are specific RNA ligands to insulin receptor antibodies, substance P and HIV intregrase identified by the SELEX method. Also included in the invention are ssDNA ligands to HIV-1 reverse transcriptase identified by the SELEX method. Also included are RNA ligands that inhibit the binding of MA-20 to the human insulin receptor, RNA ligands that are inhibitors of HIV integrase and ssDNA ligands that are inhibitors of HIV-1 reverse transcriptase.