发明名称 |
Compositions and method of stimulating the proliferation and differentiation of human fetal and adult pancreatic cells (ex vivo) |
摘要 |
A method of inducing the proliferation and/or differentiation of human fetal pancreatic cells entails contacting such cells in primary culture with Hepatocyte Growth Factor/Scatter Factor, thereby inducing a proliferation of beta -epithelial cells, an increase in the number of beta -epithelial cells which form islet-like cell clusters, and an increase in insulin production per cell. The method provides increased numbers of functional islet-like cell clusters for transplantation, for example, into Type 1 diabetic patients. The method can be scaled up so as to provide clinically useful numbers of cells for transplantation. |
申请公布号 |
AU2433695(A) |
申请公布日期 |
1995.11.29 |
申请号 |
AU19950024336 |
申请日期 |
1995.04.28 |
申请人 |
UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPA;THE WHITTIER INSTITUTE FOR DIABETES AND ENDOCRINOLOGY |
发明人 |
JEFFREY RUBIN;TIMO PYRY JUHANI OTONKOSKI;GILLIAN M BEATTIE;ALBERTO HAYEK;VITO QUARANTA |
分类号 |
A61K35/12;A61K35/39;A61P3/08;C12N5/071 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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