发明名称 Catheter system for controllably releasing a therapeutic agent at a remote tissue site
摘要 A catheter having a therapeutic agent chemically bonded to a substrate on its exterior surface using a linker which photolytically releases the agent upon exposure to light energy at an appropriate wavelength. The linker is attached to the substrate via a complementary chemical group, with the opposing end containing an aromatic ring with a nitro group in the ortho position relative to a methyl or ethyl group which is functionalized to accept a complementary bond to the therapeutic agent. The substrate may include materials such as glass, polyamide, polyester, polyolefin, polypropylene, polyurethane, or latex. The therapeutic agent may include peptides, proteins, steroids, carbohydrates, nucleotides, or other aliphatic or heterocyclic products, and may be bonded to a molecular lattice or meshwork to accommodate a high molecular concentration per unit area and the inclusion of ancillary compounds such as markers or secondary emitters.
申请公布号 US5470307(A) 申请公布日期 1995.11.28
申请号 US19940214051 申请日期 1994.03.16
申请人 LINDALL, ARNOLD W. 发明人 LINDALL, ARNOLD W.
分类号 A61L29/14;A61L29/16;A61M25/00;A61N5/06;(IPC1-7):A61M1/00 主分类号 A61L29/14
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