摘要 |
The present invention is related to substituted pyrazolyl benzenesulfonamides of the Formula I <CHEM> wherein R<2> is selected from hydrido, C1-C10-alkyl, C1-C6-haloalkyl, C1-C6-alkoxycarbonyl, cyano, carboxyl, C1-C6-cyanoalkyl, aminocarbonyl, C1-C6-alkylaminocarbonyl, C3-C7-cycloalkylaminocarbonyl, arylaminocarbonyl, C1-C6-carboxyalkylaminocarbonyl, aryl-C1-C6-alkoxycarbonyl-C1-C10-alkylaminocarbonyl, C1-C6-aminocarbonylalkyl, C1-C6-carboxyalkyl, C1-C6-alkoxycarbonylcyano-C2-C6-alkenyl and C1-C6-hydroxyalkyl; wherein R<3> is selected from hydrido, C1-C10-alkyl, cyano, C1-C6-hydroxyalkyl, C3-C7-cycloalkyl, C1-C6-alkylsulfonyl, and halo; and wherein R<4> is selected from optionally substituted C3-C10-cycloalkyl, C3-C10- cycloalkenyl and heterocyclic; provided R<2> and R<3> are not both hydrido, further provided that R<4> is not triazolyl when R<2> is methyl; and further provided that R<4> is not substituted thienyl when R<2> is trifluoromethyl; or a pharmaceutically-acceptable salt thereof. The invention is also related to pharmaceutical compositions containing such compounds. |