| 摘要 |
PURPOSE:To obtain the subject polymer useful as a polymer material having degradability and absorbability in an organism in high yield, by culturing a fungus belonging to the genus Aureobasidum, capable of producing L-malic acid polymer in a medium containing a specific amount of an organic nitrogen source and a Mg ion. CONSTITUTION:A fungus belonging to the genus Aureobasidum [e.g. Aureobasidum sp. A-91 strain (FERM P-11,966), etc.], capable of producing L-malic acid polymer, is inoculated into a medium containing 0.1-2wt.% of an organic nitrogen source (e.g. yeast essence) and 0.2-30mM of a Mg ion (e.g. magnesium sulfate) and subjected to shaking culture at 25 deg.C for three days to give a preculture mixture. The preculture mixture is added to the same medium as the previous culture, subjected to shaking culture at 25 deg.C for three days and the culture mixture is centrifuged to collect a supernatant liquid, which is concentrated, mixed with an organic solvent such as methanol and precipitated. The precipitate is filtered off and dried to give the objective L- malic acid polymer degradability and absorbability in an organism, useful as suture, a material for osteosynthesis, a carrier for a medicine, etc. |
