| 摘要 |
Substd. heterocyclic carboxylic acid amide derivs. of formula (I) are new: Q = O, S or NR<4>; X = O or S; Y = CR<3> or N; m = 0-1; A = 1-AC alkylene (opt. mono or di substd. by halo, CN, NO2, CF3, 1-6C alkyl, 1-6C hydroxy-alkyl,1-6C alkoxy, O(CH2)xCfH2f+1-g Halg, esp. 1-8C fluoroalkoxy, 1-8C fluoroalkenyloxy, 1-8C fluoroalkynyloxy, OCF2Cl or OCF2CHFCl), 1-6C alkylmercapto,etc.; B = CO2H, CONHCOR"',etc.; R"' = e.g. aryl, heteroaryl 3-7C cycloalkyl,etc.; R<1>, R<3> = H, 1-8C alkyl, 1-8C alkoxy,etc.; R<2> = e.g. a carboxylic acid isoteric gp.;R<4> = opt. branched 7-20C alkyl,6-16C aryl, etc.; or R<1>+R<4> = a chain (CH2)o(in which 1 or 2 CH2 gps. of the satd. or mono C=C unsatd. chain are opt. replaced by O, S, SO,SO2 or NR<1> and O = 3-5); R<7> = H, 6-12C aryl, 5-8C alkyl, 1-8C alkoxy (1-8C)-alkyl, 7-12C aralkoxy (1-18C) alyl, 6-12C aryloxy-(1-18C)alkyl,1-10C alkanoyl, opt. substd. 7-16C aralkanoyl or opt. substd. 6-12C aroyl; f = 1-8; g = 0 to 2f+1; x = 0-3; h = 3-6. |
